Cardiology and Healthcare

Biography

Biography: Rabia Shabir Ahmad

Abstract

Phytochemicals have been a part of human society from old times to prevent from various maladies because most of drugs were prepared from the plants. During the last few years, scientific investigations have proposed several modules like diet based regimen to prevent life threatening disorders including obesity, hypercholesterolemia and related health problems including cardiovascular diseases. Obesity is a worldwide lifestyle-related disorder increasing at an alarming rate. Among contributory factors, dietary habits are considered one of reasons for its expansion. Among various prevention strategies, a promising tool is the use of functional/nutraceuticals foods that not only improve consumer health and wellness but also reduce disease risk with minimal cost. For the reason, functional ingredients are getting attention to improve lipid metabolism and control obesity and allied disorders. In this context, green tea is an important tool to improve thermogenesis and fat oxidation. Diabetes and obesity are the common metabolic syndromes related with expansion of coronary diseases. Green tea has significant role in body weight reduction that is due to its capability to activate β-oxidation of fatty acids. Moreover, Peroxisome Proliferators Activated Receptors (PPARs) transcriptionally regulate the expression of many lipid-metabolizing enzymes, including acyl-CoA oxidase and medium chain acyl-CoA dehydrogenase. Nuclear Factor-kB (NF-kB) is reported to inhibit PPARα mediated activation of PPAR response element-driven promoter through physical interaction of PPARα with NF-kB p65. Green tea inhibits the activation of NF-kB thereby regulate the transcription of PPAR-related genes by reducing the NF-kB activation that might lead to upregulation of the lipid metabolizing enzymes thus controlling lipid level and risk of coronary diseases.