28^th International Conference on Cardiology and Healthcare August 09-11, 2018 Abu Dhabi, UAE

Biography:

Abstract:

The number of bioresorbable polymer coating stents that are commercially available is increasing. They present some potential benefits by eliminating the need for long-term polymer exposure as well as other appealing characteristics that facilitate and enhance endothelial coverage. Since its launch, several trails investigated the safety and efficacy of the bioresorbable stents. In 2014, the Century II trial compared the Ultimaster with Xience Everolimus-eluting stent with the circumferentially-coated durable polymer (Abbot Vascular). This trial concluded that the ultimaster is non-inferior to Xience Everolimus DES in its primary endpoint which was target vessel failure TVF. In another word, it showed excellent performance at a low rate of risk events. However, less is known regarding the effect of these new devices. The type of ISR and how it’s different regarding time course, morphology and more importantly in the clinical events. A 59-year-old female presented to the cardiology clinic with a history of recent angina. Her risk factors included dyslipidemia, type-II diabetes mellitus and previous PCI to both the Right Coronary Artery (RCA) with Terumo Ultimaster 2.5×38 mm Stent and the Circumflex artery (CX) using Abbot Xience Pro 2.25×23 m for non-ST elevation myocardial infarction in 2017. Stress echocardiogram proved reversible ischaemia in LAD and RCA regions and repeat catheterisation revealed an image angiographically compatible with significant In-Stent Restenosis (ISR) at mid-RCA stent; the CX showed moderate lesion just proximal to the previous stent which was widely patent and a severe proximal LAD disease. Surgical MDT was in favour of PCI as RCA anatomy distal to the stent is not graftable. For the RCA ISR treatment, we opted to perform Optical Coherence Tomography (OCT) for better characterisation of the lesion; this showed appropriate deployment of the stent, some areas with micro vessels and per-strut low-intensity signals suggestive of endothelial dysfunction, intimal hyperplasia with interestingly focal areas of inflammation suggestive of polymer hypersensitivity. The ISR was treated with DES pre-dilated for optimisation. The global literature and data on Ultimaster ISR and management (a paclitaxel-coated balloon or a drug-eluting stent) are scarce and to the very best of our knowledge, this case is one of the first descriptions of Ultimaster in-stent restenosis (or failure) secondary to possibly polymer allergic reaction. The use of intracoronary OCT imaging as an advanced imaging tool provided us with a unique opportunity to understand and manage complex and infrequent conditions like this one.

Biography:

Minkyung Kim completed her MPH from Korea University and completed her PhD course from Seoul National University, College Of Medicine. She worked as a Clinical Professor at Seoul National University Hospital from 2011 till 2014. She is a Consultant Cardiology at Sheikh Khalifa Specialty Hospital, RAK, UAE.

Abstract:

There is a sub-type of Takotsubo, a reverse Takotsubo, or Squid syndrome. We report a case of a 19-year-old man who presented with chest pain to emergency department and had hypertensive crisis. He had no medical history, recently relocated to United Arab Emirates and had trouble to get visa. He had struggle with his sponsor person for two days and has developed persistent chest pain and dizziness. In the emergency department, his initial blood pressure was 240/110 mm/Hg and it was fluctuating down to 100/70 mm/Hg. His troponin was positive and ECG showed no specific finding. Coronary angiography was done via right radial artery on 21^st of Feb 2018, showed normal coronary. We did evaluation for secondary hypertension. From abdominal CT scan, we found retroperitoneal mass (suspicious of paraganglioma). TTE showed depressed EF with basal to mid akinesia and hyperactive apical part, which was compatible with reverse Takotsubo. With medical treatment, he was recovered well, his EF improved upto 51% and RWMA disappreared. 24 hours urine collection was done. Dopamin was 538 ug/24hr (normal range is~510 ug/24hr), epinephrine was 88 ug/24hr (0~20 ug/24hr), norepinephrine was 3431 ug/24hr (0~135 ug/24hr), metanephrine was 141 pg/mL (0~62 pg/mL), normetanephrine 3303 pg/mL (0~145 pg/mL), aldosterone was 9.9 ng/dL (0.0~30.0 ng/dL). Patient discharged with medication and went back to his home contury for further evaluation and surgery. The mechanism of Takotsubo syndrome or stress induced cardiomyopathy is not known. The surge of catecholamine in the stress condition was suggested as one of possible cause of Takotsubo syndrome.

Biography:

Rabia Shabir Ahmad has completed her PhD in Food Technology from National Institute of Food Science and Technology. She has also been awarded “Letter of Appreciation” for short duration completion of PhD. Her areas of interest are functional foods, human nutrition and food science. She is currently Administrating various HEC funded research project as principal investigator. She has published papers in well reputed international and national journals. She has participated in different conferences, trainings and workshops. She is also certified instructor from United States Department of Agriculture (USDA).

Abstract:

Phytochemicals have been a part of human society from old times to prevent from various maladies because most of drugs were prepared from the plants. During the last few years, scientific investigations have proposed several modules like diet based regimen to prevent life threatening disorders including obesity, hypercholesterolemia and related health problems including cardiovascular diseases. Obesity is a worldwide lifestyle-related disorder increasing at an alarming rate. Among contributory factors, dietary habits are considered one of reasons for its expansion. Among various prevention strategies, a promising tool is the use of functional/nutraceuticals foods that not only improve consumer health and wellness but also reduce disease risk with minimal cost. For the reason, functional ingredients are getting attention to improve lipid metabolism and control obesity and allied disorders. In this context, green tea is an important tool to improve thermogenesis and fat oxidation. Diabetes and obesity are the common metabolic syndromes related with expansion of coronary diseases. Green tea has significant role in body weight reduction that is due to its capability to activate β-oxidation of fatty acids. Moreover, Peroxisome Proliferators Activated Receptors (PPARs) transcriptionally regulate the expression of many lipid-metabolizing enzymes, including acyl-CoA oxidase and medium chain acyl-CoA dehydrogenase. Nuclear Factor-kB (NF-kB) is reported to inhibit PPARα mediated activation of PPAR response element-driven promoter through physical interaction of PPARα with NF-kB p65. Green tea inhibits the activation of NF-kB thereby regulate the transcription of PPAR-related genes by reducing the NF-kB activation that might lead to upregulation of the lipid metabolizing enzymes thus controlling lipid level and risk of coronary diseases.

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