Hossein Tabriziani
Balboa Institute of Transplantation, USA
Title: Kidney transplant and improve cardiovascular outcomes
Biography
Biography: Hossein Tabriziani
Abstract
The prevalence of kidney disease and End Stage Renal Disease (ESRD) continues to rise in the world. By the year 2030, the number of patients with ESRD in USA is projected to exceed 2.2 million. This is more than five times the current prevalence. During the past decade, kidney transplantation has increasingly been recognized as the treatment of choice for medically suitable patients with ESRD. As well as improving quality of life, successful transplantation confers major benefits by improving morbidity and mortality of ESRD patients who receive kidney transplant over those who undergo Renal Replacement Therapy (RRT). Cardiovascular (CV) risk reduction remains the leading cause of this improvement. There are many reasons for this drastic success in reduction of CV death. Higher Glomerular Filtration rate (GFR) usually result in lower incidence of high blood pressure. Many kidney transplant recipients are experiencing a significant improvement in blood pressure control with fewer medications within months of surgery. Oxidative stress also plays a key role in the pathophysiological process of uremia and its complications, particularly in cardiovascular disease. The level of oxidative stress markers is known to increase as Chronic Kidney Disease (CKD) progresses and correlates significantly with level of renal function. Successful kidney transplantation results in near normalization of the antioxidant status and lipid metabolism by eliminating free radicals despite the surge of oxidative stress caused by the surgical procedure and ischemic injury to the organ during the operation. This success is associated with both improved renal functions, reduced cardiovascular complications and overall improved morbidity and mortality.