Elena Leonova
Federal Central Tuberculosis Research Institute, Russia
Title: Factors associated with right ventricular dysfunction among patients with pulmonary sarcoidosis
Biography
Biography: Elena Leonova
Abstract
Background & Aim: Arterial Stiffness (AS) is one of the most potent prognostic factors of cardiovascular morbidity and
mortality. Obesity has many effects on cardiovascular structure, function and hemodynamics. Effects of AS and Body Mass
Index (BMI) on the Right Ventricle (RV) function among patients with Pulmonary Sarcoidosis (PS) are unknown. The aim is to investigate the RV systolic dysfunction by several echocardiographic parameters among patients with PS and determine how it is associated with AS and BMI.
Method: We identified 82 patients with biopsy-proven pulmonary sarcoidosis, who underwent echocardiography, spirometry, Diffusing Capacity of Carbon Monoxide (DLCO), plethysmography. Pulmonary High Resolution Computed Tomography (HRCT) was assessed by Kazerooni scale (ground-glass and fibrosis). Aortic Pulse Wave Velocity (PWV), BMI were evaluated. RV systolic function was assessed among all subjects using different methods (Tricuspid Annular Plane Systolic Excursion (TAPSE), RV myocardial Performance Index (MPI) and RV systolic excursion velocity by tissue Doppler (S’)).
Result: RV systolic dysfunction was found in 17% of subjects by TAPSE, 19.5% by RV MPI and S’. All parameters of RV systolic
function correlated with DLCO (p<0.01), total lung capacity (p<0.001), HRCT, PWV (p<0.01). In multivariate regression
analysis the factors associated with RV systolic dysfunction were the PWV (p=0.006), HRCT (p=0.001).
Conclusion: The systolic function of the RV is associated with lungs involving and arterial stiffness. BMI has not shown any
correlation with RV systolic dysfunction.