Congenital Heart Disease (CHD) and Pediatric Cardiology

Heart failure is a complex clinical disorder which is a outcome of various primary and secondary causes, and shared pathways of disease progression, relating with considerable mortality, morbidity and cost. Heart failure in pediatrics is most commonly associated with coexistence of congenital heart disease, with different risks depending on the specific type of malformation. The signs and symptoms in children include, poor growth, feeding difficulties, respiratory track disorders, exercise intolerance, and fatigue, and is associated with circulatory, neurohormonal imbalance, and molecular abnormalities. Congenital heart disease is frequently associated with ventricular dysfunction, volume or pressure overload.

Heart Failure in pediatric patients with CHD has various causes, some of which overlap with the causes of cardiomyopathy, resulting in both distinct and shared mechanisms leading to ventricular dysfunction and the clinical manifestation of heart failure. We focus on basic, translational, and clinical research as it applies to heart failure in pediatric patients with CHD

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